Canadian Felix Auger-Aliassime proved too strong for former champion Andy Murray, cutting short the Briton's Grand Slam comeback at the US Open with a breezy 6-2, 6-3, 6-4 victory in the second round on Thursday.
Kim Clijsters and Venus Williams fell at the first hurdle
Fifth seed Simona Halep narrowly avoided a third-round upset with a 6-1, 2-6, 6-4 win over Hungary's Timea Babos on Saturday to keep her US Open title hopes alive.
Maria Sharapova's outfit sparkled even if her play sometimes didn't during her grand slam return at the US Open but the former world number one's run to the fourth round showed she is back in business on and off the court.
Tennis ace Martina Navratilova has married her long-term partner Julia Lemigova in New York.
Second seed Roger Federer powered to a 6-4, 6-3, 6-2 win over Roberto Bautista on Tuesday, charging into the quarter-finals of the US Open for the 10th time in 11 years.
Despite boasting 34 Grand Slam singles titles between them, Serena Williams and Roger Federer were forced to share the spotlight with a 15-year-old at the US Open on Tuesday as all three advanced to the second round.
How former champion Juan Martin del Potro won the crowd at US Open is amazing.
A summary of Wednesday's action at the US Open on Day 3.
Marathon man Kei Nishikori secured a monumental upset by sweating out a 6-4, 1-6, 7-6(4), 6-3 win over world number one Novak Djokovic at the U.S. Open on Saturday to become the first Japanese man to reach a Grand Slam final.
Defending champion Rafael Nadal failed to win a single game in the opening set of his US Open quarter-final against Dominic Thiem on Tuesday but fought back to beat the Austrian 0-6, 6-4, 7-5, 6-7 (4), 7-6 (5) in match that ended past 2 am in New York.
Djokovic struggled with both his serve and backhand during a 6-4, 7-6(3), 6-1 win over Argentine Juan Ignacio Londero and later said his left shoulder had been bothering him for weeks with the pain getting worse during the match.
Monday was also the first time in more than two decades that India had more than one player in the main draw of a Grand Slam singles, with Prajnesh Gunneswaran losing to world number five Daniil Medvedev in an earlier match.
Nadal claimed his second grand slam title of the year -- having won the French Open in June -- beating No. 28 seed Kevin Anderson of South Africa in straight sets 6-3, 6-3, 6-4 at Arthur Ashe Stadium in Flushing, on Sunday.
"Sloane is truly one of my favourite people and to get to play her was really special," said Keys.
Sharapova, making her return to top-flight tennis after serving a doping ban, defeated Romanian Halep 6-4, 4-6, 6-3 to move into the 2nd round of the final major of the year.
Kevin Anderson spoiled the American party at the US Open when the big-serving South African beat local favourite Sam Querrey 7-6(5), 6-7(9), 6-3, 7-6(7) to reach his first Grand Slam semi-final on Tuesday.
With Serena bidding to become just the fourth woman to win all four grand slams in the same year, the US Open hype machine that already had been in top gear is now set to crank into overdrive.
Fourth seed Kei Nishikori's hopes of making another magical U.S. Open run came to a quick end on Monday as last year's runner-up fell at the first hurdle, falling 6-4, 3-6, 4-6, 7-6 (6), 6-4 to Frenchman Benoit Paire.
World number one Novak Djokovic lost to rivals Roger Federer and Andy Murray in the finals of US Open warm-up events but the Serb insists those defeats have aided his preparations for the last grand slam of the season.
Serena Williams crushed older sister Venus 6-1, 6-2 in a shockingly subdued third round clash at the US Open on Friday to stay on track for a record equalling 24th Grand Slam title.
Garbine Muguruza was once again left to sift through the remains of another failed US Open campaign after the third-seeded Spaniard suffered a shock 7-5 6-4 second round upset by unheralded Latvian Anastasija Sevastova on Wednesday.
Ana Konjuh was not a year old when Serena Williams played her first US Open match but both will be in the Arthur Ashe Stadium spotlight on Wednesday, with four gripping quarter-finals to take centre stage at the year's final Grand Slam.
Venus Williams moved within two wins of a possible sisterly showdown with Serena in the semi-finals of the US Open by beating German 26th seed Laura Siegemund to reach the fourth round on Saturday.
Defending champion Naomi Osaka of Japan was upset 7-5, 6-4 by Belinda Bencic in the fourth round at the US Open on Monday as the Swiss reached the quarter-finals for the second time.
'I know earlier in the tournament I said something in kind of a bad way and now I'm saying it in a good way: That it's because of your energy that I'm in the final'
With Roger Federer and 2018 champion Novak Djokovic having already made exits, Nadal's path to a fourth US Open trophy has been cleared of familiar hurdles.
'I really like the way he plays, mixes in the slice, the dropshot, volleys really well. There's so many things I like from his game. Hopefully I can keep working on those and become just like him'
Big-serving Canadian Milos Raonic fired 19 aces to topple Sam Querrey 6-4, 6-4 and set up a second-round clash with either Dan Evans or Russian 10th seed Andrey Rublev.
A golden moment for Australian Ashleigh Barty and American CoCo Vandeweghe was tinged with disappointment when tournament officials did not let them speak to the crowd after winning the U.S. Open women's doubles final on Sunday.
More shocking than his departure was the manner of the 3-6, 7-5, 7-6 (7), 7-6,(3) loss to the Australian, with Federer simply wilting in the suffocating humidity and exiting a Grand Slam before the quarter-finals for just the fifth time since 2004.
Spinner Nathan Lyon believes Australia have enough time to chase the 412 victory target and win the first Ashes Test against England at Cardiff
IMAGES from Day 2 of the US Open played at Flushing Meadows in New York on Tuesday.
Images from Day 10 of the 2021 US Open in New York on Thursday.
Roger Federer handed Nick Kyrgios a 6-4 6-1 7-5 tennis masterclass by storming into the fourth round of the U.S. Open on Saturday with a ruthless display that left the Australian talking to himself and waving the white flag.
'It's always going to be ... in the years to come, 'oh, you know that guy won a US Open in 2020 without fans'. I don't think it's going to have that weight... It wouldn't be the best scenario.'
Karolina Pliskova suffered a narrow US Open defeat at the hands of Angelique Kerber on Saturday, but the Czech 10th seed also proved her mettle as one of the most dangerous attacking players in women's tennis.
Serena Williams will be wary of another semi-final slip-up when she takes to the Arthur Ashe Stadium court on Thursday to face 10th seed Karolina Pliskova for a spot in the US Open final.
Serena Williams stormed into the US Open quarter-finals in record-smashing style on Monday by easing past Kazakhstan's Yaroslava Shvedova 6-2, 6-3 to claim her record 308th Grand Slam match win.
Novak Djokovic heads into his US Open final clash with Juan Martin del Potro on Sunday knowing he faces a challenge - a very big challenge indeed.